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Warm Substances in PI3K/Ark/mTOR inhibitor Catalogue

PI3K

LY294002

CAS No. 154447-36-6

LY294002 is the very first man-made molecule recognized to hinder PI3Kα/δ/β with IC50 of .5 μM/.57 μM/.97 μM in cell-cost-free assays, respectively more stable in remedy than Wortmannin, plus obstructs autophagosome development.

Akt

Perifosine

CAS No. 157716-52-4

Perifosine (KRX-0401) is really a innovative Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology website of Akt. Stage 3.

mTOR

Everolimus

CAS No. 159351-69-6

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM inside a mobile-free assay.

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