Very hot Compounds in Protease Inhibitor Library


MG-132 CAS No. 133407-82-6

MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-cost-free assay, as well as inhibits calpain with IC50 of 1.2 μM.

20S proteasome

Bortezomib CAS No. 179324-69-7

Bortezomib (PS-341) can be a powerful 20S proteasome inhibitor with Ki of .6 nM within a mobile phone-cost-free assay.


Carfilzomib CAS No. 868540-17-4

Carfilzomib (PR-171) is definitely an permanent proteasome inhibitor with IC50 of <5 nM in ANBL-6 tissues, showcased preferential in vitro inhibitory power versus the ChT-L exercise from the β5 subunit, but little if any impact on the PGPH and T-L routines.

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