ALK inhibitor
Brigatinib Substance StructureBrigatinib
Brigatinib can be a highly potent and picky investigational ALK inhibitor with mean IC50 value ＜ 100 nM in Ba/F3 tissue.
Reference Generation: LDN193189, LDK378(Ceritinib)
JAK inhibitor
Solcitinib Substance CompositionSolcitinib
Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. Solcitinib may be possible a good choice for treatments for psoriasis，systemic lupus erythematosus, ulcerative colitis.
Reference point Production: TG101209 , TAK901
Opioid Receptor Inhibitor
Protopine Chemical substance FrameworkProtopine
Protopine can be a benzylisoquinoline alkaloid. It has been identified to hinder histamine H1 receptors and platelet aggregation, and works for an analgesic.
Reference point Manufacturing: Eluxadoline , JTC-801
SHP2 Inhibitor
SHP099 hydrochloride Chemical substance ConstructionSHP099 hydrochloride
SHP099 hydrochloride is a picky and orally bioavailable little-molecule SHP2 inhibitor with IC50 of .071 μM.
Guide Production: Molsidomine
PARP Inhibitor
VerbascosideSubstance CompositionVerbascoside
Verbascoside (Acteoside TJC160), can be a bioactive polyphenol from essential olive oil mill wastewater with acknowledged antioxidant action proteins kinase C inhibitor.
Research Creation: JNJ-42041935 , Daprodustat
EGFR Inhibitor
Anlotinib Substance FrameworkAnlotinib
Anlotinib can be a EGFR inhibitor extracted from patent 2015185012 A1, compound 1，which enables you to handle non-modest cell cancer of the lung.
Research Production: OSI-420 , Varlitinib
Pathway
Proteases/Proteasome
Chromatin/Epigenetic
JAK/STAT signaling
Tyrosine Kinase/Adaptors
PI3K/Akt/mTOR Signaling
MAPK Signaling
Apotosis
Ubiquitination
Angiogenesis
Immunology/Inflammation
DNA Injury/DNA Maintenance
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